Especially Suited for Above-Knee Bypass

• Dynaflo^® Bypass Grafts are the only grafts specially created to address the unique hemodynamics at the distal anastomosis of above-knee femoral-popliteal, axillary-femoral, femoral-femoral, and axillary-bifemoral bypass grafts.

• Unique cuff geometry provides higher flow velocities by creating a vortex at the heel of the cuff^1-2; this may help increase wall shear stress to inhibit neointimal
  thickening³

Continuing the Evolution of Cuff Design

• Hemodynamic studies indicate that different cuff configurations work best for different parts of the anatomy in reducing the risk of intimal hyperlasia^1-6
• Established examples include Distaflo^® Bypass Graft, especially suited for below-the-knee and distal-tibia procedures
  – Creates a vortex to increase wall shear stress and
     reduce flow split
• The next step in anastomotic engineering, Dynaflo^® Bypass Graft, is designed to effect favorable hemodynamics especially in above-knee and extra-anatomic bypass applications

Featuring Carbon-Impregnated Surface Technology

• Carbon-impregnated ePTFE vascular grafts, compared to a similar graft without carbon, are associated with a decrease in platelet adhesion and fibrin deposition*
  
  * These grafts, however, are not associated with any change in
     patency or reduced embolism in animal studies

Representation of carbon impregnated within the fibril and node microstructure of the graft’s luminal wall.

Meeting Surgeon Preferences and Clinical Requirements

• Cuff is pre-formed, assuring surgeons a
  consistent shape
• Available in 7 and 8 mm diameters, 50 and 60 cm lengths especially suited for above-knee femoral popliteal bypass
• Available with flex small beading in 7 and 8 mm diameters, 50, 60, 70 and 80 cm lengths especially suited for above-knee femoral-popliteal, axillary-femoral, femoral-femoral, and axillary-bifemoral bypass

References

1. Harris P. How T. Haemodynamics of cuffed arterial anastomoses.
Critical Ischaemia. 1999;9(No. 1):20-26.
2. Fisher RK, How TV, Toonder IM, et al. Harnessing haemodynamic forces for the suppression of anastomotic intimal hyperlasia: the rationale for precuffed grafts. Eur J Vasc Endovasc Surg.
2001;21:520-528.
3. Meyerson SL, Skelly CL, Curi MA, et al. The effects of extremely low shear stress on cellular proliferation and neointimal thickening in the failing bypass graft. J Vasc Surg. 2001;34(No. 1):90-97.
4. Stonebridge PA, Prescott RJ, Ruckley CV. Randomized trial comparing infrainguinal polyetrafluoroethylene bypass grafting with and without vein interposition cuff at the distal anastomosis. J Vasc Surg. 1997;26(No. 4):543-550.
5. Gagne PJ, Martinez J, DeMassi R, et al. The effect of a venous anastomosis Tyrell vein collar on the primary patency of arteriovenous grafts in patients undergoing hemodialysis. J Vasc Surg.
2000;32:1149-1154.
6. Lemson MS, Tordoir JHM, van Det RJ, et al. Effects of a venous cuff at the venous anastomosis of polytetraflouroethylene grafts for hemodialysis vascular access. J Vasc Surg. 2000;32:1155-1163.

Please consult product labels and package inserts for indications, contraindications,
hazards, warnings, cautions and information for use.

Bard, Dynaflo and Distaflo are registered trademarks of C. R. Bard, Inc., or an affiliate.
Copyright 2005 C. R. Bard, Inc. All rights reserved.
Variously protected by one or more of the following U.S. Patents: 5,641,443; 5,827,327;
5,861,026; 6,190,590; 6,203,735; 6,221,101; and 6,436,135.
U.S. and foreign patents pending. Legal Notice